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KMID : 0854720120320030159
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Korean Journal of Asthma, Allergy and Clinical Immunology
2012 Volume.32 No. 3 p.159 ~ p.168
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Change of Inflammatory Markers in Induced Sputum in Suspected Asthmatics by Asthma Treatment
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Sim Myoung-Ki
Choi In-Seon S.
Kim Woo-Jin
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Abstract
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Background: Eosinophilic airway inflammation is characteristic for typical asthma, but neutrophilic inflammation has been found in severe asthmatics resistant to steroid therapy. This study aimed to evaluate responses to asthma treatment according to inflammatory cell types in sputum.
Methods: For a cross-sectional study, 240 consecutive patients with suspected asthma who underwent a 4.5% saline-induced sputum test and a test for airway hyperresponsiveness to methacholine or for airway reversibility were enrolled. Of these patients, 23 who inhaled corticosteroids were entered to a follow-up sputum study.
Results: The number of sputum eosinophils was significantly related to the forced expiratory volume in one second/ forced vital capacity (r=?0.180, P＜0.05) and airway hyperresponsiveness (r=?0.222, P＜0.01), and the number of neutrophils was significantly related to age (r=0.165, P＜0.05) and forced expiratory volume in one second (r=?0.157, P＜ 0.05). Subjects with sputum eosinophilia (n=88, 20.5%) had received asthma treatment before the tests more often than those with neutrophilia (n=23, 4.3%) or mixed granulocytic nature (n=11, 0%) (P＜0.05 for each). In the follow-up study, the number of eosinophils was significantly decreased in the eosinophilic subjects (P＜0.05), and the ?interferon-?/interleukin-5 ratio was significantly related to ?eosinophils (r=0.933, P＜0.001). There was an inverse relationship between the number of neutrophils and the increase in forced expiratory volume in one second (r=?0.459, P＜0.05) or ?interferon-? (r=?0.842, P＜0.01).
Conclusion: The severity of asthma may depend on inflammatory cell types in sputum. Although inflammatory markers of sputum improve by asthma treatment, treatment responses differ according to cell types. Therefore, sputum examination may be useful for predicting therapeutic responses in asthmatics.
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KEYWORD
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Asthma, Eosinophils, Neutrophils, Sputum, Treatment
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